Design

PROFILE is a randomised, multi-centre, biomarker-stratified open-label trial in patients newly diagnosed with Crohn’s disease.

Aim

PROFILE aims to demonstrate that a prognostic biomarker can enable delivery of personalised therapy in Crohn's disease, and that this improves clinical outcomes.

Setting

PROFILE will recruit trial participants at approximately 50 acute hospital trusts across the UK.

Target Population

PROFILE aims to recruit 400 adults with newly diagnosed Crohn’s disease. Newly diagnosed is defined as within the last three months.

Funding

The PROFILE trial is being funded by the Wellcome Trust as part of their translational grant award funding stream.

Page last updated: 8th August 2018